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nitko to ne radi utorkom pdf download

nitko to ne radi utorkom pdf download

Genetic defects As with the above-mentioned markers of aneuploidy, defects of DNA repair can also be assayed in buccal cell samples. Some important classes of DNA repair defects include inherited syndromes, errors in DNA polymerases, and defects in mismatch repair genes. These defects are inherited in an autosomal dominant manner. For instance, in the case of Lynch syndrome, the most commonly studied DNA repair disorder in hereditary cancer syndromes, it has been established that the affected gene (which is currently known as hMSH2) occurs in homozygous form in about 10–15% of cases of sporadic colon cancers. For the remaining 90–95% of cases, the function of the gene is either normal or it is heterozygous, leading to expression of both the normal and defective gene products. Concerning the inactivation of mismatch repair genes, as this could be relevant in tumour detection and prevention, it has been proposed to consider MSH6, MSH2 and MLH1 genes to be good markers of tumour risk in the general population (see "Tumour detection and prevention"). However, concerning this issue, substantial research needs to be conducted to establish whether their evaluation is useful for cancer risk prediction, or whether it is possible to use these genes only for tumour detection. Heterozygous mutations of base excision repair genes may also influence the risk of the development of many types of cancer. For instance, heterozygous mutation in the p53 gene is associated with increased cancer risk. Bacteria and viruses By analogy with mammalian systems, there is considerable interest in the relationship between DNA polymorphisms and the risk of cancer (see here). Several genes have been described as mutated in a variety of tumour types, including the VHL gene. However, the contribution of these polymorphisms to cancer risk is still a matter of debate. Cancer tests The ability to detect mutations in human DNA is an important component of several preventive and therapeutic strategies in the oncology context. Examples of such strategies include tumour immunology-based vaccines (see here) and the use of various polychemotherapeutic drugs (see here) in combination with surgery or radiotherapy. A biomarker that could indicate the presence of genetic alterations in pre-cancerous lesions could represent a significant step forward in tumour prevention and early diagnosis. In the past few years, advances in human cancer genetics and

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Nitko To Ne Radi Utorkom Pdf Download dalbkea

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